Custom PCBs come in a few categories: home-made by etching, using a PC-board milling machine, and using a PC-board manufacturer. Of these, only the last one is practical for computer circuit boards. (Reserve your home etching for analog circuits, or better yet, build them on prototyping boards like Radio Shack's 276-170 (yes, they still sell them online, as of 12/12/20) or, similar but better, BPS's BR1, both shown below.)
Etching your own boards at home for computer circuits is mostly impractical because of the requirements for fine lines and thru-plating the holes. A few have used a laser printer to make masks and used various techniques to transfer the pattern to the board. KC9UDX on the forum says he has done down to .005" trace & space this way. As impressive as that is, I imagine there's a very high risk of problem boards!
The milling option (which does not use photographic or chemical means) works well, but the up-front cost of the machine is prohibitive for the hobbyist. I'm referring to machines like LPKF sells, which, under the control of your computer, actually mills the copper instead of etching it chemically. Their bottom-of-the-line model is shown here. You would have to be doing loads of double-sided boards to justify the purchase price.
Fortunately, the cost of using PC-board manufacturers has come well within the reach of hobbyists. Until around the late 1990's, PC boards cost never less than about $400 for the lot (and went up from there, depending on the number of manufacturing steps), even if it were only two boards, because of the manufacturing set-up costs. Don't forget that that was more money back then than it is today.
Then PCB Express (now part of Sunstone) and others started offering a low-cost prototyping service getting the price of your entire order as low as $60 or so (for small, double-sided boards). There were certain limitations, like that they only offered 16 hole sizes (so an operator wouldn't have to load other drill bits into the machine just for your project), the shape of the board had to be a variation of a rectangle, there was no soldermask or silkscreen for the rock-bottom price, etc.. Apparently they would take your files and make your boards on the same panel with other customers' boards, and handle them mostly by computer with little or no human CAM (computer-aided manufacturing) operator time. This cut costs, but it means you have to be especially careful to get things right at your end. If you have a problem resulting from traces too close together or crossing each other or not coming all the way up to pads, they won't catch it for you, let alone fix it or call you up. What you order is what you get. There are other board houses like Imagineering which are more expensive but still good for small production runs of more-complex boards, and they will give your design more human CAM attention.
We have a forum topic, "Cheap PCB stories..." It started in 2011, so you'll see progress as the topic goes from one page to the next, to the next. Another forum I'm on has a similar topic, "Getting boards fabricated (Recommendations?)"
Using CAD (ie, computer-aided design software) and getting custom PC boards made is certainly an option for prototyping and the hobbyist. There are some low-cost CAD packages, and some free ones. Some prototyping board houses have had their own CAD (Express PCB comes to mind, not to be confused with PCB Express, now part of Sunstone) which you can download free but which does not produce industry-standard files, meaning that if you decide you don't like the board house's service or price, you can't just send your files to another board house. (That's probably on purpose, huh?) I would recommend using only CAD that produces industry-standard gerber RS-274X (not the older 274D) gerber files (gerber is for the photoplotting, ie for the copper layers, soldermask, legend, and solderpaste—the "graphics" part of the board) and excellon drill files. Some board houses will accept some popular CADs' files directly, without your having to gerberize first, for example Eagle's *.brd files; but if you want to make sure you're not limited, make sure the CAD can produce gerber 274X files if needed.
Wikipedia has a brief comparison of a long list of CADs, many of them free, at https://en.wikipedia.org/wiki/Comparison_of_EDA_software. See also http://pcbshopper.com/cad/ for some info and reviews on free PCB CAD.
There are gerber viewers available to double-check your CAD file output. I use gerbv which is free (at least for Linux, and I suspect for Windows too). I see there's also a free 3D online gerber viewer at http://mayhewlabs.com/3dpcb.
One fear I have heard is that narrow traces will be delicate and break easily. Not so. If the board is flexed, a narrow trace gets the same percentage of stretch as a wide one running next to it. No difference. PCB manufacturers usually go down to .006"-wide trace and space before they add extra charges. Even in 1993 I remember seeing boards with traces whose width was the same as their height (ie, thickness) with sharp corners and straight-up sides. How they can make a trace with a square cross section is beyond me, but they can do it, if you want to pay.
Another fear I have heard expressed is that holes' thru-plating, espicially for vias, won't be reliable. (Vias are the plated-thru holes that are only there to connect a trace on one layer to a trace on another layer of a board.) In the company I've worked for since 1992, virtually all of our products have used multi-layer boards, with vias of course, and we've never had any trouble. In the company where I worked the previous seven years, we only had 2-layer (ie, double-sided) boards, again with vias of course, and did not have any problems. I do not let the via size get below one-quarter of the board thickness; IOW, a .062"-thick PCB's vias will be .015", not less, but a .031"-thick board's vias can go down to .008". They have been totally reliable. (These are finished hole sizes. The drill bit will be slightly larger, then the plating inside the hole reduces the diameter a little, arriving at the finished hole size.) Now most board houses seem to be allowing up to at least an 8:1 aspect ratio, meaning a .062"-thick board can have .008" vias.
The last two paragraphs' reassurance should help you pack it in, if you had previously been afraid to make the traces so thin or or the vias so small. I don't limit myself to 0°, 45°, and 90° trace angles, although letting them be any angle is more useful in analog than it is in digital. Here's a nearly wall-to-wall parts layout for a card made to go in a 3U Eurocard cage (3U VME?) from the timeline on Dieter's pages on 6502.org:
Incidentally, I still do my schematics by hand, since there are things about all of the schematic CADs that I don't like. At my last job, I got very proficient at OrCAD for schematic capture, but it was terrible. Now I go straight from hand-drawn schematics to PCB CAD, without using netlists & rat's nesting, etc.. And using this method of checking, I don't get any errors either. To give an example of the extreme density I've done with thru-hole (we do mostly SMT now though), see this portion of a mostly-analog PC board, first with U5 in the top-left corner missing (to show all the parts that go under the IC), and then with it installed. I put up to 11 resistors and diodes under each 14-pin IC, staggered in five rows:
The maximum density I've gotten with thru-hole, as an across-the-board average (IOW, big parts pulling the average down), was 45 parts per square inch. The most populous thru-hole analog board I ever laid out was the main board of the aircraft intercom shown near the bottom of the "Address Decoding" section, which had about 500 parts on a 3.8"x4.8" 12-layer PCB. (I did that one with a DOS-based CAD on a 16MHz '286 with 1MB of RAM, and it didn't need all the RAM to do it either!)
There are various online tools at https://www.eeweb.com/ for helping
determine things like trace width, wire inductance, transmission-line impedance, microstrip crosstalk, etc..
Off-Topic: Breadboarding Analog Circuits
This is off the topic of making the computer itself, but I have used dozens of the Radio Shack 276-170 analog prototyping PC boards which have the same pattern that the common solderless breadboards with the hundreds of plug-in contacts have.
Unfortunately in the spring of 2017, Radio Shack is going out of business (see a related forum topic); but I know other companies are selling virtually identical ones. I'll try to update this with links. I checked the link again in Dec 2020 and it was still good. I thought it was just to liquidate, but maybe they will keep selling online.
A similar one but with more buses plus holes at the ends for connectors, are several of BusBoard Prototype Systems' soldered breadboards shown here. Here's one of them:
You can download their 2019 .pdf catalog from the front page of their website.
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last updated Dec 12, 2020